N-term: NH2
Sequence: ECESGPCCRNCKFLKEGTICKRARGDDMDDYCNGKTCDCPRNPHKGPAT
(Modifications: Disulfide bridge between 2 - 11, 7 - 32, 8 - 37, 20 - 39)
C-term: Acid
Molecular Weight = 5417.1
Description:
The H-9019 peptide, also known as echistatin by scientific terminology, is a 49-amino acid polypeptide, or chain, with 4 cystine bridges from the venom of a snake, the saw-scaled viper (known as Echis carinatus). The polypeptide contains an RGD sequence that binds to glycoprotein receptors on platelets and inhibits ADP-stimulated platelet aggregation with IC50 = 3.3 x 10(-8) M. In addition, the peptide stimulates osteolastic bone resportion, both in vitro and in vivo; and, the reduction of purified synthetic echistatin to octahydroechistatin with dithiothreitol, combined with air oxidation, regenerated a quantitative yield of identical echistatin sequences.
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